Role of LRRK2 in axonal transport and Parkinson’s disease.
Twellsieck B and Boecker CA.
Biochemical Journal. 2025, 905–919 https://doi.org/10.1042/BCJ20253133

Protocol for live imaging of axonal transport in iPSC-derived iNeurons.
Dou D, Holzbaur ELF, Boecker CA.
STAR Protocols. 2025 Mar 21;6(1):103556. doi: 10.1016/j.xpro.2024.103556. 

Knockout of the LRRK2-counteracting RAB phosphatase PPM1H disrupts axonal autophagy and exacerbates alpha-synuclein aggregation.
Fricke, M., Mechel, A., Twellsieck, B., Grein, J.M., Cima-Omori, M.-S., Zweckstetter, M., Holzbaur, E.L.F., Boecker, C.A.

Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes.
Dou D, Smith EM, Evans CS, Boecker CA, Holzbaur ELF.
Cell Reports. 2023 May 30;42(5):112448. doi: 10.1016/j.celrep.2023.112448.

The Role of LRRK2 in Intracellular Organelle Dynamics.
Boecker CA.
Journal of Molecular Biology. 2023 Jun 15;435(12):167998. doi: 10.1016/j.jmb.2023.167998.

Distinct adaptations revealed by unbiased proteomic analysis of autophagy cargos in the brain in PINK1 and LRRK2 models of Parkinson’s disease
J Goldsmith, A Ordureau, AKH Stavoe, CA Boecker, M Arany, JW Harper, ELFHolzbaur

Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes.
Boecker CA, Goldsmith J, Dou D, Cajka GG, Holzbaur ELF.
Current Biology. 2021 May 24;31(10):2140-2154.e6. doi: 10.1016/j.cub.2021.02.061.

Hyperactive LRRK2 kinase impairs the trafficking of axonal autophagosomes.
Boecker CA, Holzbaur ELF.
Autophagy. 2021 Aug;17(8):2043-2045. doi: 10.1080/15548627.2021.1936933.

Actin cables and comet tails organize mitochondrial networks in mitosis.
Moore AS, Coscia SM, Simpson CL, Ortega FE, Wait EC, Heddleston JM, Nirschl JJ, Obara CJ, Guedes-Dias P, Boecker CA, Chew TL, Theriot JA, Lippincott-Schwartz J, Holzbaur ELF.
Nature. 2021 Mar;591(7851):659-664. doi: 10.1038/s41586-021-03309-5.

Structural basis for membrane recruitment of ATG16L1 by WIPI2 in autophagy.
Strong LM, Chang C, Riley JF, Boecker CA, Flower TG, Buffalo CZ, Ren X, Stavoe AK, Holzbaur EL, Hurley JH.
Elife. 2021 Sep 10;10:e70372. doi: 10.7554/eLife.70372.

ToolBox: Live Imaging of intracellular organelle transport in induced pluripotent stem cell-derived neurons.
Boecker CA, Olenick MA, Gallagher ER, Ward ME, Holzbaur ELF.
Traffic. 2020 Jan;21(1):138-155. doi: 10.1111/tra.12701.

TUBB4A mutations result in both glial and neuronal degeneration in an H-ABC leukodystrophy mouse model.
Sase S, Almad AA, Boecker CA, Guedes-Dias P, Li JJ, Takanohashi A, Patel A, McCaffrey T, Patel H, Sirdeshpande D, Curiel J, Shih-Hwa Liu J, Padiath Q, Holzbaur EL, Scherer SS, Vanderver A.
Elife. 2020 May 28;9:e52986. doi: 10.7554/eLife.52986.

Inhibition of the autophagic protein ULK1 attenuates axonal degeneration in vitro and in vivo, enhances translation, and modulates splicing.
Vahsen BF, Ribas VT, Sundermeyer J, Boecker A, Dambeck V, Lenz C, Shomroni O, Caldi Gomes L, Tatenhorst L, Barski E, Roser AE, Michel U, Urlaub H, Salinas G, Bähr M, Koch JC, Lingor P.
Cell Death & Differentiation. 2020 Oct;27(10):2810-2827. doi: 10.1038/s41418-020-0543-y.

Vesicular degradation pathways in neurons: at the crossroads of autophagy and endo-lysosomal degradation.
Boecker CA, Holzbaur EL.
Current Opinion in Neurobiology. 2019 Aug;57:94-101. doi: 10.1016/j.conb.2019.01.005.

Transient opening of the perineurial barrier for analgesic drug delivery.
Hackel D, Krug SM, Sauer RS, Mousa SA, Böcker A, Pflücke D, Wrede EJ, Kistner K, Hoffmann T, Niedermirtl B, Sommer C, Bloch L, Huber O, Blasig IE, Amasheh S, Reeh PW, Fromm M, Brack A, Rittner HL.
PNAS. 2012 Jul 17;109(29):E2018-27. doi: 10.1073/pnas.1120800109.

A peptidomimetic tight junction modulator to improve regional analgesia.
Zwanziger D, Hackel D, Staat C, Böcker A, Brack A, Beyermann M, Rittner H, Blasig IE.
Molecular Pharmaceutics. 2012 Jun 4;9(6):1785-94. doi: 10.1021/mp3000937. Epub 2012 May 10.