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The Role of LRRK2 in Intracellular Organelle Dynamics.
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Distinct adaptations revealed by unbiased proteomic analysis of autophagy cargos in the brain in PINK1 and LRRK2 models of Parkinson’s disease
J Goldsmith, A Ordureau, AKH Stavoe, CA Boecker, M Arany, JW Harper, ELFHolzbaur

Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes.
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Curr Biol. 2021 May 24;31(10):2140-2154.e6. doi: 10.1016/j.cub.2021.02.061. Epub 2021 Mar 24.

Hyperactive LRRK2 kinase impairs the trafficking of axonal autophagosomes.
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Autophagy. 2021 Aug;17(8):2043-2045. doi: 10.1080/15548627.2021.1936933. Epub 2021 Jun 10.

Actin cables and comet tails organize mitochondrial networks in mitosis.
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Structural basis for membrane recruitment of ATG16L1 by WIPI2 in autophagy.
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ToolBox: Live Imaging of intracellular organelle transport in induced pluripotent stem cell-derived neurons.
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TUBB4A mutations result in both glial and neuronal degeneration in an H-ABC leukodystrophy mouse model.
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Inhibition of the autophagic protein ULK1 attenuates axonal degeneration in vitro and in vivo, enhances translation, and modulates splicing.
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Vesicular degradation pathways in neurons: at the crossroads of autophagy and endo-lysosomal degradation.
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Curr Opin Neurobiol. 2019 Aug;57:94-101. doi: 10.1016/j.conb.2019.01.005. Epub 2019 Feb 19.

Transient opening of the perineurial barrier for analgesic drug delivery.
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A peptidomimetic tight junction modulator to improve regional analgesia.
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